Annals of Movement Disorders

REVIEW ARTICLES
Year
: 2022  |  Volume : 5  |  Issue : 1  |  Page : 1--11

Evolution of eye movement abnormalities in Huntington’s disease


Khushboo Patel, Nitish Kamble, Vikram V Holla, Pramod K Pal, Ravi Yadav 
 Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Ravi Yadav
Professor of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru - 560029, Karnataka
India

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. Eye movement abnormalities are characteristic manifestations of HD. The clinical manifestations and eye movement disturbances progress with the natural course of illness. Eye movement abnormalities evolve in HD from the premanifest stage to the early-manifest and late-manifest stages. In the premanifest stage, voluntary saccades, i.e., memory-guided saccades and anti-saccades are predominantly affected. There is an increase in latency and error rates of voluntary saccades. Early-manifest stage of HD is characterized by abnormality in reflexive saccades, with decrease in saccadic amplitude and velocity and slow broken pursuits. In the late-manifest stage, initiation of voluntary saccades in all directions is slow, leading to difficulty in initiating voluntary eye movements. The rate of progression of the saccades, pursuits, and other ocular movement correlate with the disease progression; monitoring this helps in early disease evaluation and in evaluating novel therapies to modify the disease. In this article, we systematically review the available literature on the patterns and progression of eye movement abnormalities, from the premanifest, to manifest, and advanced stages of HD.


How to cite this article:
Patel K, Kamble N, Holla VV, Pal PK, Yadav R. Evolution of eye movement abnormalities in Huntington’s disease.Ann Mov Disord 2022;5:1-11


How to cite this URL:
Patel K, Kamble N, Holla VV, Pal PK, Yadav R. Evolution of eye movement abnormalities in Huntington’s disease. Ann Mov Disord [serial online] 2022 [cited 2022 May 22 ];5:1-11
Available from: https://www.aomd.in/article.asp?issn=2590-3446;year=2022;volume=5;issue=1;spage=1;epage=11;aulast=Patel;type=0