Annals of Movement Disorders

ORIGINAL ARTICLES
Year
: 2021  |  Volume : 4  |  Issue : 3  |  Page : 121--130

Burden of nonmotor symptoms in Parkinson’s disease patients from eastern India


Sulagna Sahu1, Adreesh Mukherjee1, Samar Biswas1, Valentina Leta2, Katarina Rukavina2, Shyamal Kumar Das1, Atanu Biswas1 
1 Department of Neurology, Institute of Post Graduate Medical Education & Research (IPGME&R) and Bangur Institute of Neurosciences, Kolkata, West Bengal, India
2 Parkinson’s Foundation Centre of Excellence at King’s College Hospital and King’s College London, London, UK

Correspondence Address:
Prof. Atanu Biswas
Department of Neurology, Bangur Institute of Neurosciences and IPGME&R, 52/1A, S.N. Pandit Street, Kolkata 700025, West Bengal.
India

BACKGROUND: Parkinson’s disease (PD) is classically characterized by motor features. However, nonmotor symptoms (NMSs) represent an important aspect of the disease with a significant impact on quality of life (QoL). OBJECTIVES: The aim of this study was to evaluate NMS in patients with PD, to determine their various correlates, and to assess the impact on QoL. METHODS: This cross-sectional study included 150 consecutive patients with PD and 150 age- and sex-matched healthy controls. NMSs were assessed using the NMS Questionnaire (NMSQuest) and NMS Scale (NMSS). QoL was evaluated by the 8-item Parkinson’s Disease Questionnaire scored as summary index (PDQ-8-SI). RESULTS: Every patient experienced NMS and 90% had more than five NMSs. Patients with PD had a significantly higher prevalence of NMS compared to healthy controls. The most common NMSs in patients with PD were unexplained pain, anxiety, constipation, insomnia, and memory impairment. Miscellaneous was the most prevalent domain of NMSS, followed by sleep/fatigue, gastrointestinal tract, and mood/cognition. Attention/memory impairment and pain were greater in females. Cardiovascular/falls and perceptual/hallucination showed a positive correlation with duration of disease. Sexual dysfunction decreased with increasing age. In the young-onset group (YOPD), mood/cognition involvement was higher. PDQ-8-SI showed a significant correlation with total NMSS score and most of the individual domain scores. Contrary to other Indian studies, our patients reported restless legs more frequently, whereas urinary symptoms were less common. Our observations showed a greater prevalence of pain and constipation compared to the Western studies. CONCLUSIONS: All of our patients experienced NMS. The prevalence of various NMS in our study showed differences with previous reports. NMS had a significant impact on QoL.


How to cite this article:
Sahu S, Mukherjee A, Biswas S, Leta V, Rukavina K, Das SK, Biswas A. Burden of nonmotor symptoms in Parkinson’s disease patients from eastern India.Ann Mov Disord 2021;4:121-130


How to cite this URL:
Sahu S, Mukherjee A, Biswas S, Leta V, Rukavina K, Das SK, Biswas A. Burden of nonmotor symptoms in Parkinson’s disease patients from eastern India. Ann Mov Disord [serial online] 2021 [cited 2022 May 27 ];4:121-130
Available from: https://www.aomd.in/article.asp?issn=2590-3446;year=2021;volume=4;issue=3;spage=121;epage=130;aulast=Sahu;type=0