• Users Online: 73
  • Print this page
  • Email this page
REVIEW ARTICLES
Year : 2022  |  Volume : 5  |  Issue : 1  |  Page : 1-11

Evolution of eye movement abnormalities in Huntington’s disease


Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Ravi Yadav
Professor of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru - 560029, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/AOMD.AOMD_24_21

Rights and Permissions

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. Eye movement abnormalities are characteristic manifestations of HD. The clinical manifestations and eye movement disturbances progress with the natural course of illness. Eye movement abnormalities evolve in HD from the premanifest stage to the early-manifest and late-manifest stages. In the premanifest stage, voluntary saccades, i.e., memory-guided saccades and anti-saccades are predominantly affected. There is an increase in latency and error rates of voluntary saccades. Early-manifest stage of HD is characterized by abnormality in reflexive saccades, with decrease in saccadic amplitude and velocity and slow broken pursuits. In the late-manifest stage, initiation of voluntary saccades in all directions is slow, leading to difficulty in initiating voluntary eye movements. The rate of progression of the saccades, pursuits, and other ocular movement correlate with the disease progression; monitoring this helps in early disease evaluation and in evaluating novel therapies to modify the disease. In this article, we systematically review the available literature on the patterns and progression of eye movement abnormalities, from the premanifest, to manifest, and advanced stages of HD.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1984    
    Printed98    
    Emailed0    
    PDF Downloaded222    
    Comments [Add]    

Recommend this journal